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It covers the biochemistry, the evidence honestly, the regulatory status most articles skip, and how to position MIC with patients without promising something it cannot deliver

The observed regulation of SOD2 by cytokines and stress response transcription factors confirms the direct involvement of signals (paracrine or autocrine) originating from the TME

K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

PMID: 56 PreveteNLiottiFAmoresanoAPucciPde PaulisAMelilloRM

Moreover, HA functions as an active targeting moiety to recognize the transmembrane glycoprotein CD44 receptor, which is overexpressed on surfaces of various tumor cells (Song et al., 2014)